ABSTRACT
Objective To discuss the efficacy and pharmacological mechanism of Simo decoction to assist the treatment of postoperative gastrointestinal dysfunction. Methods 200 mice (100 male and 100 female) were randomly divided into four groups (n=50). The mice of blank group were feed as normal,and the mice in the other three groups were prepared for colon postoperative gastrointestinal dysfunction model. Then,trimebutine maleate group were given trimebutine maleate while the combined group were given trimebutine maleate and simo decoction through gavage,and model group and blank group were given the same doses of distilled water. One week later,the abdominal ve-nous blood of mice was extracted and serum levels of acetylcholine ( ACH) and norepinephrine ( NE) were detected using ELISA kit. At the samd time,the gastric emptying and intestinal propulsion experiment was carried on. Results After modeling,compared with blank group, MUPA of the rest three groups were significantly decreased (P0. 05). After drug intervention,MUPA of trimebutine maleate group was significantly higher than that of model group,and MUPA of combined group was significantly higher than that of trimebutine maleate group (P<0. 05). In addition,compared with blank group,the gas-tric emptying rate,intestinal propulsion rate,serum ACH concentration and NE concentration of the rest three groups were significantly lower (P<0. 05). Compared with model group,each index of both trimebutine maleate group and combined group was increased,and combined group increased higher (P<0. 05). Conclusion Simo decoction combined trimebutine maleate has high effect to improve the level of ACH and NE of postoperative gastrointestinal dysfunction mice,which benefit to promote gastrointestinal peristalsis and may be one of its pharmaco-logical mechanisms.